Journal Papers
  A Multiscale Blob Representation of Mammographic Parenchymal Patterns and Mammographic Risk Assessment
Z. Chen, L. Wang, E. Denton and R. Zwiggelaar, Lecture Notes in Computer Science, Vol. 8048, pp. 346-353 (2013).
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Segmentation of biomedical images using active contour model with robust image feature and shape prior
S. Y. Yeo, X. Xie, I. Sazonov, and P. Nithiarasu, International Journal for Numerical Methods in Biomedical Engineering, accepted, 2013.
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Unsupervised tumour segmentation in PET using local and global intensity-fitting active surface and alpha matting
Z. Zeng, J.Wang, B. Tiddeman and R. Zwiggelaar, Computers in Biology and Medicine (-), pp. - (2013).
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Integrated Segmentation and Interpolation of Sparse Data
A. Paiement, M. Mirmehdi, X. Xie, and M. Hamilton, IEEE Transactions on Image Processing (T-IP), accepted, 2013.
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Surgical Trainee Opinions in the United Kingdom Regarding a Three-Dimensional Virtual Mentoring Environment (MentorSL) in Second Life
Usman Jaffer, Nigel W. John, and Nigel Standfield. Pilot Study - JMIR Serious Games 1.1 (2013): e2.
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Automatic Bootstrapping and Tracking of Object Contours
J. Chiverton, X. Xie, and M. Mirmehdi, IEEE Transactions on Image Processing (T-IP), volume 21, issue 3, pages 1231 - 1245, March 2012.
No image available Machine learning methods on exhaled volatile organic compounds for distinguishing COPD patients from healthy controls
C.O. Phillips, Y. Syed, N. Mac Parthalain, R. Zwiggelaar, T.C. Claypole and K.E. Lewis,- Journal of Breath Research 6 (3), (2012).
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Geometrically Induced Force Interaction for Three-Dimensional Deformable Models
S. Yeo, X. Xie, I. Sazonov and P. Nithiarasu, IEEE Transactions on Image Processing (T-IP), volume 20, number 5, pages 1373 - 1387, IEEE CS Press, May 2011.
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Shape and Appearance Priors for Level Set-based LV Segmentation
R. Yang, M. Mirmehdi, X. Xie, and D. Hall, IET Journal of Computer Vision, vol. 7, no.3, pp. 170-183, 2013.
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Interventional Radiology Virtual Simulator for Liver Biopsy
P.F.Villard,  F.P. Vidal,  L. ap Cenydd,  R. Holbrey,  S. Pisharody, S. Johnson,  A. Bulpitt,  N.W. John,  F. Bello,  D. Gould, International Journal of Computer Assisted Radiology and Surgery. Available on line in advance of print. DOI: 10.1007/s11548-013-0929-0.
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ImaGiNe Seldinger: first simulator for Seldinger Technique and Angiography Training
V. Luboz, Y. Zhang, S. Johnson, Y. Song, C. Kilkenny, C. Hunt, H. Woolnough, S. Guediri, J. Zhai, T. Odetoyinbo, P. Littler, A. Fisher, C. Hughes, N. Chalmers, D. Kessel, P. J. Clough, J. Ward, R. Phillips, T. How, A. Bulpitt, N. W. John, F. Bello, D. Gould, Comput. Methods Prog. Biomed. 2013 Aug;111(2):419-34 DOI: 10.1016/j.cmpb. 2013.05.014.
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An Overview on Interactive Medical Image Segmentation
F. Zhao and X. Xie - Annals of the British Machine Vision Association (BMVA), 2013.  vol. 2013, no. 7, 1 - 22
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Medical Mentoring in the evolving World Wide Web", Journal of Surgical Education
U. Jaffer, E. Vaughan-Huxley, N. Standfield, N.W. John, Journal of Surgical Education, 70(1), pp 121-8January/February 2013. doi: 10.1016/j.jsurg.2012.06.024.
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A Stable and Real-time Nonlinear Elastic Approach to Simulating Guide-wire and Catheter Insertions based on Cosserat Rod", IEEE Transactions on Biomedical Engineering
Wen Tang, Tao Ruan Wan, Derek A Gould, Thien How, and Nigel W John, IEEE Transactions on Biomedical Engineering, 2012. Early Access Articles. doi: 10.1109/TBME.2012.2199319
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Glioblastoma blood flow measured with stable xenon CT indicates tumor necrosis, vascularity, and brain invasion
M. Crocker, S. Saadoun, A. Jury, C. Jones, S. Zacharoulis, S. Thomas, R. Zwiggelaar, L.R. Bridges, B.A. Bell, and M.C. Papadopoulos. Neuro-Oncology 14 (5), 641-648 (2012).
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Visualizing the Surface of a Living Human Brain
L. ap Cenydd, N.W. John, M. Bloj, A. Walter, N.I. Phillips,  IEEE Computer Graphics and Applications, vol.32, no.2, pp.55-65, March-April 2012, doi: 10.1109/MCG.2011.105
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Integrating Haptics with Augmented Reality in a Femoral Palpation and Needle Insertion Training Simulation
T.R. Coles, N.W. John, D.A. Gould and D.G. Caldwell, IEEE Transactions on Haptics: Special Issue on Haptics in Medicine and Clinical Skill Acquisition, September 2011. To appear
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A new approach to haptic rendering of guidewires for use in minimally invasive surgical simulation
D. Huang, W. Tang, T.R. Wan, N.W. John, D. Gould, Y. Ding, Y. Chen - Computer Animation and Virtual Worlds, Special Issue: CASA' 2011, Volume 22, Issue 2-3, pages 261-268, April - May 2011, DOI: 10.1002/cav.417
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The Role of Haptics in Medical Training Simulators: A Survey of the State of the Art
T. R. Coles, D. Meglan, N. W. John, IEEE Transactions on Haptics, vol. 4, no. 1, pp. 51-66, Jan.-Mar. 2011, doi:10.1109/TOH.2010.19
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Modelling pipeline for subject-specific arterial blood flow
I. Sazonov, S.Y. Yeo, R.L.T Bevan, X. Xie, R. van Loon, P. Nithiarasu, International Journal for Numerical Methods in Biomedical Engineering, volume 27, issue 12, December 2011.
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Medical Image Understanding and Analysis 2012 Special Issue, Annals of the BMVA
Xianghua Xie, Guest Editor, Annals of the BMVA, vol. 2013, 2013.
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Mammographic image segmentation and risk classification based on mammographic parenchymal patterns and geometric moments
W. He, E.R.E. Denton and R. Zwiggelaar - Biomedical Signal Processing and Control 6 (3), pp. 321-329 (2011).
Refereed Conference Papers
Towards a High Fidelity Simulation of the Kidney Biopsy Procedure
Gareth Henshall, Serban R Pop, Marc R Edwards, Llyr ap Cenydd, Nigel W John, - IEEE VR 2015 Posters.
Hung, G. M., John, N. W., Hancock, C., & Hoshi, T. (2014). Using and Validating Airborne Ultrasound as a Tactile Interface within Medical Training Simulators. In Biomedical Simulation, F. Bello and S. Cotin (Eds.): ISBMS 2014, LNCS 8789, pp. 30-39. Springer International Publishing.
Interactive segmentation of media-adventitia border in OCT
J.-L. Jones, E. Essa, X. Xie and J. Cotton, Interactive segmentation of media-adventitia border in OCT, In Proceedings of International Conference on Computational and Mathematical Biomedical Engineering, accepted, December 2013.
Investigation of a Virtual Environment for Rugby Skills Training
Helen C. Miles, Serban R. Pop, Simon J. Watt, Gavin P. Lawrence, Nigel W. John, Vincent Perrot, Pierre Mallet and Daniel R. Mestre, "Investigation of a Virtual Environment for Rugby Skills Training",
Cyberworlds 2013, Yokohama, Japan, October 2013.
Unsupervised Cells Segmentation Based on Morphology and Adaptive Active Contour Modelling
Z Zeng, H Strange, C Han and R Zwiggelaar. Unsupervised Cells Segmentation Based on Morphology and Adaptive Active Contour Modelling. Accepted to ICIAR 2013 - Lecture Notes in Computer Science Volume 7950, 2013, pp 605-612
Graph Based Segmentation with Minimal User Interaction
H. Zhang, E. Essa, and X. Xie, Graph Based Segmentation with Minimal User Interaction, In Proceedings of IEEE International Conference on Image Processing, pages 4074-4078, September 2013.
Efficient reconstruction of coronary vessels from 2D angiography
D. Chen, J. Deng, X. Xie, P. Nithiarasu, and D. Smith, Efficient reconstruction of coronary vessels from 2D angiography, In Proceedings of International Conference on Computational and Mathematical Biomedical Engineering, accepted, December 2013.
Graph Based Segmentation with Minimal User Interaction, In Proceedings of IEEE International Conference on Image Processing,
H. Zhang, E. Essa, and X. Xie, Graph Based Segmentation with Minimal User Interaction, In Proceedings of IEEE International Conference on Image Processing, pages 4074-4078, September 2013.
Image Segmentation using Combined User Interactions, In Proceedings of the Computational Visual Media Conference,
J. Jones, X. Xie, and E. Essa, Image Segmentation using Combined User Interactions, In Proceedings of the Computational Visual Media Conference, September 2013.
Interactive Segmentation of Media-Adventitia Border in IVUS
J.-L. Jones, E. Essa, X. Xie, and D. Smith, Interactive Segmentation of Media-Adventitia Border in IVUS, In Proceedings of 15th International Conference on Computer Analysis of Images and Patterns, pages 466-474, August 2013.
UltraPulse Simulating a Human Arterial Pulse with Focussed Airborne Ultrasound",
G.M.Y. Hung, N.W. John, C. Hancock, D.A. Gould and T. Hoshi, "UltraPulse Simulating a Human Arterial Pulse with Focussed Airborne Ultrasound", IEEE Engineering in Medicine and Biology, Osaka, Japan, July 2013, pp2511-2514, July 2013.
Fuzzy-Entropy based Image Congealing
N MacParthalain and H Strange. Fuzzy-Entropy based Image Congealing. Accepted for FUZZ-IEEE 2013.
Manifold Learning for Density Segmentation in High Risk Mammograms.
H Strange, E R E Denton, M Kibiro and R Zwiggelaar.  Manifold Learning for Density Segmentation in High Risk Mammograms.  Iberian Conference on Pattern Recognition and Image Analysis, June 2013.
Meningioma subtype classification using morphology features and random forests
H Strange, R Zwiggelaar, Meningioma subtype classification using morphology features and random forests, Proc. SPIE 8676, Medical Imaging 2013: Digital Pathology, 86760S (March 29, 2013); doi:10.1117/12.2001786.
Shape Prior Model for Media-Adventitia Border Segmentation in IVUS using Graph Cut, In MICCAI Medical Computer Vision
E. Essa, X. Xie, I. Sazonov, P. Nithiarasu, D. Smith, Shape Prior Model for Media-Adventitia Border Segmentation in IVUS using Graph Cut, In MICCAI Medical Computer Vision, September 2012.
Efficient Geometrical Potential Force Computation for Deformable Model Segmentation
Sazonov, X. Xie, P. Nithiarasu, Efficient Geometrical Potential Force Computation for Deformable Model Segmentation, In MICCAI Medical Computer Vision, September 2012.
A Directed Particle System for Optimised Visualization of Blood Flow in Complex Networks
S.R. Pop, C.J. Hughes, L. ap Cenydd, N. W. John, "A Directed Particle System for Optimised Visualization of Blood Flow in Complex Networks", NextMed Medicine Meets Virtual Reality 20, J.D. Westwood et al. (Eds.), Stud Health Technol Inform. 2013;184:330-6. IOS Press, 2013.
Medical Image Segmentation Using Magnetostatic Active Contours (MAC) with Tensor Diffusion
H. Zhang and X. Xie, Medical Image Segmentation Using Magnetostatic Active Contours (MAC) with Tensor Diffusion, In Proceedings of the 16th Conference on Medical Image Understanding and Analysis, July 2012.
Graph-based Segmentation of Optimal IVUS Media-Adventitia Border using Shape Prior
E. Essa, X. Xie, I. Sazonov, P. Nithiarasu, D. Smith, Graph-based Segmentation of Optimal IVUS Media-Adventitia Border using Shape Prior, In Proceedings of the 16th Conference on Medical Image Understanding and Analysis, July 2012.
Segmentation and Mesh Generation for Patient-Specific Flow Modelling in Carotid Arteries,
I. Sazonov, X. Xie, S. Y. Yeo, R. Bevan, R. van Loon, P. Nithiarasu, Segmentation and Mesh Generation for Patient-Specific Flow Modelling in Carotid Arteries, In Proceedings of the 16th Conference on Medical Image Understanding and Analysis, July 2012.
GPF Deformable Model based Vessel Segmentation in CT, In Proceedings of the 16th Conference on Medical Image Understanding and Analysis
S. Y. Yeo, X. Xie, I. Sazonov, P. Nithiarasu, GPF Deformable Model based Vessel Segmentation in CT, In Proceedings of the 16th Conference on Medical Image Understanding and Analysis, July 2012.
Interactive Segmentation of Medical Images: A Survey, In Proceedings of the 16th Conference on Medical Image Understanding and Analysis
F. Zhao and X. Xie, Interactive Segmentation of Medical Images: A Survey, In Proceedings of the 16th Conference on Medical Image Understanding and Analysis, July 2012.
An adaptive MRI denoising method using self-snakes with a Rayleigh smoothing kernel,
H. Zhang and X. Xie, An adaptive MRI denoising method using self-snakes with a Rayleigh smoothing kernel, In Proceedings of the International Conference on Bioinformatics and Biomedical Engineering, May 2012.
Segmentation of Vessel Geometries from Medical Images using GPF Deformable Model
S. Yeo, X. Xie, I. Sazonov, P. Nithiarasu, Segmentation of Vessel Geometries from Medical Images using GPF Deformable Model, In Proceedings of the International Conference on Pattern Recognition Applications and Methods, February 2012.
Automatic Microcalcification and Cluster Detection for Digital and Digitised Mammograms.
A. Oliver. X.Torrent. M. Llado, L. Tortajada, M. Tortajada, J. Sentıs, Freixenet, R. Zwiggelaar. Automatic Microcalcification and Cluster Detection for Digital and Digitised Mammograms. Knowledge-Based Systems (2011).
Automatic Segmentation of IVUS Media-Adventitia Border with Shape Prior
E. Essa, X. Xie, I. Sazonov, P. Nithiarasu, D. Smith, Automatic Segmentation of IVUS Media-Adventitia Border with Shape Prior, In Proceedings of the 15th Medical Image Understanding and Analysis, July 2011.
A Robotic Needle Interface for Interventional Radiology Training
C.J. Hughes, N.W. John, "A Robotic Needle Interface for Interventional Radiology Training", In: Proc. The 4th Hamlyn Symposium for Medical Robotics, London, June 2011
Realistic Visualization of Living Brain Tissue", "Realistic Visualization of Living Brain Tissue
L. ap Cenydd, A. Walter, N. W. John, M. Bloj, N. Phillips, "Realistic Visualization of Living Brain Tissue", Medicine Meets Virtual Reality 18, J.D. Westwood et al. (Eds.), IOS Press, 2011, pp105-111 doi:10.3233/978-1-60750-706-2-105
Automatic IVUS Media-Adventitia Border Extraction using Double-Interface Graph Cut Segmentation
E. Essa, X. Xie, I. Sazonov, P. Nithiarasu, Automatic IVUS Media-Adventitia Border Extraction using Double-Interface Graph Cut Segmentation, In Proceedings of the 18th IEEE International Conference on Image Processing, September 2011.
Level Set Segmentation with Robust Image Gradient Energy and Statistical Shape Prior,
S. Yeo, X. Xie, I. Sazonov and P. Nithiarasu, Level Set Segmentation with Robust Image Gradient Energy and Statistical Shape Prior, In Proceedings of the 18th IEEE International Conference on Image Processing, September 2011.
Automatic Segmentation of IVUS Media-Adventitia Border with Shape Prior
E. Essa, X. Xie, I. Sazonov, P. Nithiarasu, D. Smith, Automatic Segmentation of IVUS Media-Adventitia Border with Shape Prior, In Proceedings of the 15th Medical Image Understanding and Analysis, July 2011.

Book Chapters
Poster Presentations

  • Susan Doshi, Derek Jones, and Daniel Barazany - BRANDI: Bayesian Regularisation of Advanced Neurological Diffusion Imaging, ISMRM-ESMRMB Joint Annual Meeting, Milan, May 2014.
  • M.R. Edwards, N.W.John, L. ap Cenydd, I. Shergill, “Force Sensitive Embedded Glove to Measure Axial Needle Forces with a Case Study for Transperineal Prostate Biopsies”, Eurographics Workshop on Visual Computing in Medicine and Biology, Vienna 2014.
  • Y Ding, S.R. Pop, F.P. Vidal, N.W. John, “Real-time Simulation of Peripheral Nerve Stimulation for Regional Anaesthesia”, Eurographics Workshop on Visual Computing in Medicine and Biology, Vienna 2014.
  • M.R. Edwards, N.W. John, E. Jesudason, “Metacarpal Thumb Joint Measurement and Rehabilitation with LeapMotion”, Eurographics Workshop on Visual Computing in Medicine and Biology, Vienna 2014.
  • L. ap Cenydd, N. W. John, N.I. Phillips, W.P. Gray, "VCath: A Tablet-based Neurosurgery Training Tool", NextMed Medicine Meets Virtual Reality 20, J.D. Westwood et al. (Eds.), Stud Health Technol Inform. 2013;184:202-4. IOS Press, 2013.
  • C.J. Hughes, N. W. John, "3D Measuring tool for Estimating Femoroacetabular Impingement", NextMed Medicine Meets Virtual Reality 20, J.D. Westwood et al. (Eds.), Stud Health Technol Inform. 2013;184:20-3. IOS Press, 2013. Best Poster Prize
  • T. R Coles, G. Sofia, N. W. John, D. A. Gould, D. G. Caldwell, "Modification of Commercial Force Feedback Hardware for Needle Insertion Simulation", Medicine Meets Virtual Reality 18, J.D. Westwood et al. (Eds.), IOS Press, 2011, pp135-137, doi:10.3233/978-1-60750-706-2-135. Best Poster Prize
  • F. Soler, M.V. Luzon, S.R. Pop, C.J. Hughes, N.W. John, J.C. Torres, "A Model for Flexible Tools used in Minimally Invasive Medical Virtual Environments", Medicine Meets Virtual Reality 18, J.D. Westwood et al. (Eds.), IOS Press, 2011, pp594-598, doi:10.3233/978-1-60750-706-2-594.